Azeco Cosmeceuticals

AZECO COSMECEUTICALS BV - MUSSENBERG 1, 6049 GZ Herten, The Netherlands – Phone: +31 475 782540

Local exhaust ventilation - efficiency of at least 90.0 % Advanced (industrial) exposure controls assumed C ONDITIONS AND MEASURES RELATED TO PERSONAL PROTECTION , HYGIENE AND HEALTH EVALUATION Wear suitable gloves tested to EN374 O THER CONDITIONS AFFECTING WORKERS EXPOSURE Indoor use Assumes elevated process temperature up to 40.0 °C 1.2.7. C ONTRIBUTING S CENARIO 7 - C ONTROL OF WORKER EXPOSURE : U SE A LABORATORY REAGENT (PROC 15) P RODUCT ( ARTICLE ) CHARACTERISTICS Covers percentage substance in the product up to 100 % A MOUNT USED ( OR CONTAINED IN ARTICLES ), FREQUENCY AND DURATION OF USE / EXPOSURE Covers daily exposures up to 8 hours T ECHNICAL AND ORGANISATIONAL CONDITIONS AND MEASURES Provide a basic standard of general ventilation (1 to 3 air changes per hour) Local exhaust ventilation - efficiency of at least 90.0 %

Advanced (industrial) exposure controls assumed O THER CONDITIONS AFFECTING WORKERS EXPOSURE Indoor use Assumes elevated process temperature up to 40.0 °C

2. ES 2: F ORMULATION & ( RE ) PACKING OF THE SUBSTANCE OF ITS MIXTURES

2.1. T ITLE SECTION

E NVIRONMENT Contributing Scenario 1 : Formulation & (re)packing of the substance of its mixtures W ORKER Contributing Scenario 2 : Use in closed process, no likelihood of exposure Contributing Scenario 3 : Use in closed, continuous process with occasional controlled exposure Contributing Scenario 5 : Use in batch and other processes (synthesis) where opportunity for exposure arises Contributing Scenario 6 : Mixing or blending in batch processes for formulation of preparations and articles Contributing Scenario 7 : Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at not dedicated facilities Contributing Scenario 8 : Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities Contributing Scenario 9 : Transfer of substance or preparation into small containers (dedicated filling line, including weighing) Industrial settings Contributing Scenario 10 : Production of preparations or articles by tablettings, compression, extrusion, pelettisation Contributing Scenario 4 : Use in closed batch process (synthesis or formulation)

ERC 2

PROC 1

PROC 2

PROC 3

PROC 4

PROC 5

PROC 8a

PROC 8b

PROC 9

PROC 14

REGULATION (EC) No 1907/2006 Date of Issue: 02/01/2020

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Date of Revision: - AZCO99 Revision Nr.: - Version Nr.: 1