Azeco Cosmeceuticals

AZECO COSMECEUTICALS BV - MUSSENBERG 1, 6049 GZ Herten, The Netherlands – Phone: +31 475 782540

Advanced (industrial) exposure controls assumed. O THER CONDITIONS AFFECTING WORKERS EXPOSURE Indoor use Assumes elevated process temperature up to 40.0 °C

1.2.4. C ONTRIBUTING S CENARIO 4 - C ONTROL OF WORKER EXPOSURE : U SE IN CLOSED BATCH PROCESS ( SYNTHESIS OR FORMULATION ) (PROC 3) P RODUCT ( ARTICLE ) CHARACTERISTICS Covers percentage substance in the product up to 100 % A MOUNT USED ( OR CONTAINED IN ARTICLES ), FREQUENCY AND DURATION OF USE / EXPOSURE Covers daily exposures up to 8 hours T ECHNICAL AND ORGANISATIONAL CONDITIONS AND MEASURES Provide a basic standard of general ventilation (1 to 3 air changes per hour)

Use in closed batch process (synthesis or formulation) Advanced (industrial) exposure controls assumed O THER CONDITIONS AFFECTING WORKERS EXPOSURE Indoor use Assumes elevated process temperature up to 40.0 °C

1.2.5. C ONTRIBUTING S CENARIO 5 - C ONTROL OF WORKER EXPOSURE : U SE IN BATCH AND OTHER PROCESSES ( SYNTHESIS ) WHERE OPPORTUNITY FOR EXPOSURE ARISES (PROC 4) P RODUCT ( ARTICLE ) CHARACTERISTICS Covers percentage substance in the product up to 100 %. A MOUNT USED ( OR CONTAINED IN ARTICLES ), FREQUENCY AND DURATION OF USE / EXPOSURE Covers daily exposures up to 8 hours. T ECHNICAL AND ORGANISATIONAL CONDITIONS AND MEASURES Provide a basic standard of general ventilation (1 to 3 air changes per hour) .

Use in semi-closed process with opportunity for exposure Local exhaust ventilation - efficiency of at least 90.0 % Advanced (industrial) exposure controls assumed. O THER CONDITIONS AFFECTING WORKERS EXPOSURE Indoor use Assumes elevated process temperature up to 40.0 °C

1.2.6. C ONTRIBUTING S CENARIO 6 - C ONTROL OF WORKER EXPOSURE : T RANSFER OF SUBSTANCE OR PREPARATION ( CHARGING / DISCHARGING ) FROM / TO VESSELS / LARGE CONTAINERS AT DEDICATED FACILITIES (PROC 8 B ) P RODUCT ( ARTICLE ) CHARACTERISTICS Covers percentage substance in the product up to 100 % A MOUNT USED ( OR CONTAINED IN ARTICLES ), FREQUENCY AND DURATION OF USE / EXPOSURE Covers daily exposures up to 8 hours T ECHNICAL AND ORGANISATIONAL CONDITIONS AND MEASURES Provide a basic standard of general ventilation (1 to 3 air changes per hour) Use in semi-closed process with opportunity for exposure

REGULATION (EC) No 1907/2006 Date of Issue: 02/01/2020

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Date of Revision: - AZCO99 Revision Nr.: - Version Nr.: 1