Azeco Cosmeceuticals

AZECO COSMECEUTICALS BV - MUSSENBERG 1, 6049 GZ Herten, The Netherlands – Phone: +31 475 782540

12.1. T ITLE SECTION

L ABORATORY C HEMICALS (PC 21) Manufacture of fine chemicals (SU 9) Formulation [mixing] of preparations and/or re-packaging (excluding alloys) (SU 10) E NVIRONMENT Contributing Scenario 1 : Use in laboratories

ERC 4

W ORKER Contributing Scenario 2 : Roller application or brushing

PROC 10

Contributing Scenario 3 : Use as laboratory agent

PROC 15

12.2. C ONDITIONS OF USE AFFECTING EXPOSURE

12.2.1. C ONTROL OF ENVIRONMENTAL EXPOSURE : U SE IN LABORATORIES (ERC 4)

In consideration of the chemical safety assessment, performed for this substance according to Article 14 (3) of the REACH regulation, all identified uses of azelaic acid are assessed as safe for the environment.

12.2.2. C ONTROL OF WORKER EXPOSURE : R OLLER APPLICATION OR BRUSHING (PROC 10)

P RODUCT ( ARTICLE ) CHARACTERISTICS Covers percentage substance in the product up to 100 %. A MOUNT USED ( OR CONTAINED IN ARTICLES ), FREQUENCY AND DURATION OF USE / EXPOSURE Covers daily exposures up to 8 hours T ECHNICAL AND ORGANISATIONAL CONDITIONS AND MEASURES Provide a basic standard of general ventilation (1 to 3 air changes per hour) Local exhaust ventilation - efficiency of at least 90.0 % Advanced (industrial) exposure controls assumed C ONDITIONS AND MEASURES RELATED TO PERSONAL PROTECTION , HYGIENE AND HEALTH EVALUATION Wear suitable gloves tested to EN374 O THER CONDITIONS AFFECTING WORKERS EXPOSURE Indoor use Assumes elevated process temperature up to 40.0 °C P RODUCT ( ARTICLE ) CHARACTERISTICS Covers percentage substance in the product up to 100 % A MOUNT USED ( OR CONTAINED IN ARTICLES ), FREQUENCY AND DURATION OF USE / EXPOSURE Covers daily exposures up to 8 hours T ECHNICAL AND ORGANISATIONAL CONDITIONS AND MEASURES Provide a basic standard of general ventilation (1 to 3 air changes per hour) Local exhaust ventilation - efficiency of at least 90.0 % 12.2.3. C ONTROL OF WORKER EXPOSURE : U SE AS LABORATORY AGENT (PROC 15)

Advanced (industrial) exposure controls assumed O THER CONDITIONS AFFECTING WORKERS EXPOSURE Indoor use

REGULATION (EC) No 1907/2006 Date of Issue: 02/01/2020

Page 54 of 56

Date of Revision: - AZCO99 Revision Nr.: - Version Nr.: 1