Azeco Cosmeceuticals

Developing new products from scratch is a lengthy business, as you will know and it would be up to 12 months before I could have a product ready to take to market. I need useable products NOW and so developing a prescriptive range where the products are mixed immediately prior to use is an attractive option.

Reply to Customer Customer wishes to have a base formulation containing azelaic acid. To that base formulation active ingredients can be added on demand. In this way a personalised product can be made for a particular customer. Such a base formulation can be generated by dissolution of azelaic acid in propanediol (Zemea, ex.Dupont), chemically identified as 1,3-propanediol. The solution of azelaic acid in propanediol does not require preservation and may be thickened using 3-4% hydroxy- propylcellulose (HPC; Ashland). To the obtained gel other active ingredients can be added, provided the additive is miscible with the azelaic acid/propanediol gel. That is the case for hydrophilic extracts, but also oil-in-water emulsions. The solubility of azelaic acid in propanediol is relatively high. We frequently use solutions of 10-15%. We do not know what the maxi- mum solubility of azelaic acid in propanediol would be. That would need to be researched. Note that gelation of propanediol with HPC is a tedious process.

Mussenberg 1 • 6049 GZ Roermond • The Netherlands

5