Azeco Cosmeceuticals

Question: How to improve the solubility of azelaic acid? Answer

A METHOD TO IMPROVE THE SOLUBILITY OF AZELAIC ACID

Azelaic acid is poorly soluble in water, as described earlier by Brand-Garnys & Brand. The monosodium & disodium slats are slightly better soluble but as a result the pH of these solutions is alkaline, frequently a disadvantage. Mather & Stahl (WO 1996.039119) des- cribed several combinations of solvent, frequently glycols that enable to properly dissolve azelaic acid. Example 1. 40 parts ethoxydiglycol

3 parts diisopropyl adipate 1-10% azelaic acid Mix & stir until a clear solution has been obtained.

Example 2. 40 parts dipropylene glycol 1-10% azelaic acid

Mix & stir while heating to 60°C until a clear solution has been obtained. Dipropylene glycol and ethoxydiglycol are excellent solvent systems for azelaic acid. It is recommended to further dilute the solutions of example 1 and example 2 with other glycols, more particularly propanediol (1,3-dihydroxypropane), pentylene glycol (1,2- dihy- droxypentane), glycerol, ethoxylated glycerol (glycereth-12, 18,20 & 26) and similar polyols. The solutions enable to dissolve up to 25% azelaic acid, and may function as the basis of serum preparations for use in personal care & cosmetic preparations as well as medical device, as well as a starting product for e.g. emulsion & gel preparations.

Answer Customer:

As you know from earlier my previous emails, I am looking at incorporating Azpur99 into my professional use and retail products. This includes developing a professional use ‘prescriptives’ range where I have a base gel serum product and I add to it a range of actives depending on the skin type that I am treating to make a bespoke serum. I would use that serum in the facial treatment in the clinic and I would ‘dispense’ a bespoke mix of actives that the client could then take with them for home use in conjunction with the my standard serums. My query is whether it is possible to prepare a concentration of Azpur99 that could be added to the bespoke serums?

I read in your literature that there is 15% hydrogel available - is this available to purchase?

Mussenberg 1 • 6049 GZ Roermond • The Netherlands

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