Azeco Cosmeceuticals

Azeco Cosmeceuticals — your preferred partner for the formulation of azelaic acid based skin care products Azeco Cosmeceuticals is the world’s leading supplier of cosmetic-grade azelaic acid. We earned this distinction by providing excep tional purity levels unique product in the world market having this feature), consistently reliable supply, and outstanding technical and regulatory support. Our high purity azelaic acid is manufactured and handled according to the ISO 9001:2015 certification. It is obtained by using a continuous process 24 hours a day, seven days a week. This not only ensures ready availability, it also eliminates the batch-to-batch inconsistencies often found in azelaic acid from other suppliers. Azelaic acid from Azeco Cosmeceuticals has European, 100% bioba sed and palm free origin and it is REACH (Registration Evaluation and Authorization of CHemicals) compliant. How Azepur99® works on skin When used in cosmetic formulations, azelaic acid penetrates the skin effectively and stimulates cellular activity. Azelaic acid is able to assist in normalisation of the microflora on the skin. Organisms that have become opportunistic are normalised to their normal level, including propionibacterium acnes, and it thus assists in many cases in clearing and preventing acne. The mode of action has not been fully elucidated, but in numerous preclinical and clinical studies it has been demonstrated that azelaic acid displays three main beneficial properties on impure skin: 1. It normalizes the disturbed follicular keratinization that leads to the formation of comedones.. The reduction in the count of comedones has subsequently been demonstrated in various clinical studies. 2. Azelaic acid has a significant antibacterial effect on the follicular propionibacterium acnes and Staphylococcus epidermidis (in vitro). This effect is primarily bactericidal but may in vivo be modified to a bacteriostatic one. 3. In addition azelaic acid also reveals direct anti-inflammatory activities by reducing the production and release of reactive oxygen species. Azelaic acid is also an effective inhibitor of tyrosinase, the enzyme involved in the conversion of tyrosine to melanin. So Azepur99®, according to its high purity characteristic and natural origin, can be safely used in brightening/lightening cosmetic products both for Asian and Caucasian skin. The competitive inhibition of tyrosinase by Azepur99® (see the scheme below) results in a decreased production of melanin.

Azepur99®

Azepur99®

Azepur99®

Then Azepur99® is a natural skin bleaching agent and an effective lightener for the skin. It has the advantage of giving a paler skin, naturally. Many accurate scientific publications are available in the art relatively to the mechanism of action of Azelaic acid on the skin. At the end of this document, in the paragraph dedicated to “References”, some of them are listed.

The standard for azelaic acid in pharma & cosmetics

Mussenberg 1 • 6049 GZ Roermond • The Netherlands

3