Azeco Cosmeceuticals

The aim of this monocentric open-label clinical study was to assess the clinical and instrumental efficacy and tolerability in use condi - tions of a serum containing Azelawhite® complex (oligopeptide-68 2%, azelaic acid 8%) and glycolic acid (3%) for photo-aged skin during 12 weeks. This association already demonstrated an anti-aging efficacy on human cutaneous explants. 42 Caucasian volunteers (45-70 years old) were included and analyzed. At inclusion (D0), subjects presented peri orbital wrinkles graded 3 to 6 (from 1 to 9 scale) and at least one target facial lentigo. This serum was applied on face and neck twice daily (morning and evening), clinical and instrumental photo-aging signs assessments were performed. The local score for the target lentigo improved significantly after 4, 8 and 12 weeks of serum application (42% of improvement). AEVA assessment showed a significant improvement of the rough structu - res (deep wrinkles) after 4 weeks (p=0.008). So Azelaic Acid seems very reliable for lightening the complexion, and we feel it’s a great alternative to other types of skin lighteners, here’s why: • First and foremost, it’s much safer of the main part of the available alternative products; • It’s ability to lighten complexion is also thanks to anti-inflammatory and successful ability in treating various forms of acne. Two advantages in one active ingredient. • It’s safe for all skin complexions, especially those with a deeper and darker skin tone. • It’s effective in bringing life back into dull and aged skin by brightening and evening out the tone of your skin. • Unlike hydroquinone, azelaic acid does not affect the pigments of the skin, but rather tackles abnormal melanocytes (small melanin cells) instead. 2.3 Azelaic acid in hair care products Many individuals suffer from hair loss (alopecia), especially females. One of the conditions leading to thinning hair is known as hereditary hypotrichosis simplex. The responsible gene, APCDD1, has been identified and causes hair follicles to shrink (23). Victims of genetic hairlessness also frequently face the absence of eyelashes and eyebrows. There are sincere indications that the number of people condemned to genetic baldness is limited to less than a hundred individuals worldwide; scant comfort for those with an unwanted naked scull. Virtually all individuals will face sooner or later involutional alopecia (old age hair loss) and that can only be delayed by providing the hair follicles with a frequent shot of essential nutrients (B vitamins and some metal ions). A low-protein diet or severely calorie-res- tricted diet frequently causes temporary hair loss. Alopecia areata (spot baldness) and alopecia universalis (total body hair fall-out, including eyebrows & eye lashes) are auto-immune disorders for which no general treatment is available. With Alopecia areata hair loss is observed resulting in smooth, round patches about the size of a coin or larger. It can, rarely, result in complete loss of scalp and body hair. This disease may affect children or adults of any age. The cause of alopecia areata is unknown, having said that the affected victims are generally in excellent health. In most cases, the hair regrows without intervention. Alopecia areata may also be observed with pregnant woman: during pregnancy the hair will be growing with increasing intensity (pregnant woman frequently have beautiful hair) but after delivery many hairs swiftly enter a dormant stage. Within two to three months, some women will notice large amounts of hair coming out in their brushes and combs. This can last up to half a year, but resolves complete- ly in most cases. In a number of cases sulfasalazine or anthralin (1,8-dihydroxyanthron) offer an effective treatment for alopecia areata, but superior results are obtained using azelaic acid, without the unwanted side effects of sulfasalazine and/or anthralin7 (1,8-dihy- droxyanthron). Male pattern hair loss (MPHL; androgenic alopecia) develops under the influence of androgenic hormones and is probably the most important reason for the development of baldness. Androgenic alopecia is not life-threatening. The research investments in hair growth solutions are quite significant indeed, and comparable to the investments made in research on diabetes, cancer and car - dio-vascular conditions. Investments in hair growth research are justified as the hair follicles are an important scientific model for understanding important aspects of human cell biology, organ system developmental biology, immune response medicine,

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