SERRA-BADRICH - HUMAN MICROBIOME (ROSACEA, ATOPIC DERMATITIS

Neurogenic inflammation Vascular changes

• Vascular endoltelial growth factor (VEGF) is present is the epidermis and is expressed by infiltrating cells • VEGF receptor-ligand binding contributes to vascular changes and cellular infiltrate • The intestinal vasoactive peptide (VIP) is increased in the serum and in the cutaneous blood vessels of the phymomatous R • LL37 induces cell-endothelial changes promoting vascular effects on rosacea