SERRA-BADRICH - HUMAN MICROBIOME (ROSACEA, ATOPIC DERMATITIS

Innate immunity– microbiome expression PRR modified • Are innate immune receptors expressed by keratinocytes, which release cytokines, chemokines and AMP

PRRs • TLR Toll like receptors----TLR2…..IL-10 • NOD nucleotide oligomerization domain • NLR nucleotide like receptors • CLR c-type lectin receptors • GRR G-protein coupled receptors • RIG retinoid acid inducible gene • RLR retinoid I like receptors

• TLR2 Recognize Bacterial Wall Constituents

PRR = pattern recognition receptors PAMP = pathogen associated molecular patterns