Essential Guide azelaic acid

10. Clinical research

To evaluate the performance of the Anti Acne European composition (SC002) containing 10% azelaic acid, a clinical study was conducted in 8 patients presenting closed comedones. The formulation was applied twice daily for a period of 30 days on the affected areas. Efficacy was assessed at defined intervals using a standardized visual observation scale ranging from no improvement to complete recovery. 10.1 Clinical study: Anti Acne European Formula (SC002)

SC002 Anti-acne European Formula Triple action: anti-imperfections, anti-residual marks, anti-aging

INCI Name

Trade Name

% by weight

Function

A

Aqua

Water

45.45

Solvent

Betaine

Betafin BP20 [1]

5

Emulsifier

Glycerine

Pricerine 9083 [2]

5

Humectant

Sodium Hydroxyde, 18% Aqueous Solution

Aqua, Sodium Hydroxyde

1.5

Neutralizer

B

Azelaic acid

Azepur99®

10

Active ingredient

Tripelargonin

Matrilox CP601M [5]

15

Emollient

Cetearyl Alcohol

Lanette O [4]

2

Body agent

PEG-20 Glyceryl Stearate

Cutina E24 [4]

3

Emulsifier

Glyceryl Stearate, Ceteareth-12, Ceteareth-20, Cetearyl Alcohol, Cetyl Palmitate

Emulgade SE [2]

10

Emulsifier

Diethylhexyl Adipate

Crodalmol DOA [2]

2

Emollient

C

Phenoxyethanol, Sorbitan Caprylate

Nipaguard SCP [3]

1

Preservative

D

Parfum

–

0.15

Fragrance

TABLE 15: Anti-acne Formula

Suppliers: [1] Dupont / Danisco Finnfeeds Oy [2] Croda Oleochemicals [3] Clariant / Nipa Preservatives [4] BASF / Cognis [5] Matrìca

Specifications: Appearance

Soft cream White Characteristic 4,9-5,6 5,2 7,200 11,400 mPas 8,450 mPas

Colour Odour pH Typical: Brookfield Viscosity (S4, 20 rpm, 25°C) Typical:

44

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