Azeco Cosmeceuticals

AZECO COSMECEUTICALS BV - MUSSENBERG 1, 6049 GZ Herten, The Netherlands – Phone: +31 475 782540

E XP . S CENARIO

M ARKET S ECTOR

T ITLES OF EXPOSURE SCENARIOS AND THE RELATED CONTRIBUTING SCENARIOS

- Use in closed batch process (synthesis or formulation) (PROC 3) - Use in batch and other processes (synthesis) where opportunity for exposure arises (PROC 4) - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at not dedicated facilities (PROC 8a) - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities (PROC 8b) - Transfer of substance or preparation into small containers (dedicated filling line, including weighing) Industrial settings (PROC 9) - Use as laboratory agent (PROC 15)

U SE AT INDUSTRIAL SITE - U SE IN LABORATORIES - Use in laboratories (ERC 4) - Roller application or brushing (PROC 10) - Use as laboratory agent (PROC 15) U SE BY PROFESSIONAL WORKER - U SE IN LABORATORIES - Use in laboratories (ERC 8a) - Roller application or brushing (PROC 10) - Use as laboratory agent (PROC 15)

ES12– IW7

PC 21

ES13 – PW4

PC 21

* About the use in personal care products and in drugs of azelaic acid, no exposure scenarios are calculated for these applications because these uses are exempt from REACH human assessment, already regulated respectively by the 1223/2009 EC and the 2001/83 EC. Acronyms ACGIH = American Conference of Governmental Industrial Hygienists DNEL = Derived No Effect Level EC50 = Effective Concentration 50: concentration that causes a certain effect in 50% of a population EINECS = European Inventory of Existing Commercial chemical Substances ErC50 = EC50 (growth rate): EC50 biomass growth of aquatic plants LC50 = Lethal Concentration 50: concentration that causes the death of 50% of population LD50 = Lethal Dose 50: dose that causes the death of 50% of population NOAEL = No Observed Adverse Effect Level: dose or concentration without adverse effect OECD = Organization for Economic Co-operation and Development OSHA PEL = Occupational Safety and Health Administration-Permissible Exposure Limit PNEC = Predicted No Effect Concentration

TLV = Threshold Limit Value TWA = Time-Weighted Average WGK = Wassergefährdungsklasse

Bibliography: Data are sourced from the REACH registration dossier, available on the ECHA dissemination tool web page.

DISCLAIMER: The herein opinions and information are the result of our investigations and are given in good faith but no warranty, express or implied, is made. The information refers to Azelaic acid as delivered by AZECO COSMECEUTICALS BV . Since the use of these opinions and information and the conditions of use of the product are not under the control or supervision of AZECO COSMECEUTICALS BV, it is the user’s responsibility to determine the safety and suitability for his own use of the product described herein. To this purpose the recipient is invited to consider the present MSDS in the context of the applicable laws and regulations of the country and area where the product is to be used. The products must be handled only by trained personnel.

REGULATION (EC) No 1907/2006 Date of Issue: 02/01/2020

Page 13 of 56

Date of Revision: - AZCO99 Revision Nr.: - Version Nr.: 1