Azeco Cosmeceuticals

AZECO COSMECEUTICALS BV - MUSSENBERG 1, 6049 GZ Herten, The Netherlands – Phone: +31 475 782540

9.2. O THER INFORMATION :

N OT AVAILABLE

S ECTION 10: S TABILITY AND REACTIVITY

10.1. R EACTIVITY :

Reacts with strong oxidizing agents, bases and strong acids

10.2. C HEMICAL S TABILITY :

Stable under normal storage conditions.

10.3. P OSSIBILITY OF HAZARDOUS REACTIONS :

Not expected in normal storage and use conditions

10.4. C ONDITIONS TO A VOID :

Flames, ignition sources, excessive heat.

10.5. I NCOMPATIBLE MATERIALS :

Strong oxidizing agents, bases and strong acids.

10.6. H AZARDOUS DECOMPOSITION PRODUCTS :

Carbon oxides during combustion.

S ECTION 11: T OXICOLOGICAL INFORMATION

11.1. I NFORMATION ON TOXICOLOGICAL EFFECTS :

A CUTE T OXICITY :

read across from OCTANOIC ACID ( CAS 124-07-2) LD50 ORAL , RAT > 5000 mg/kg bw

OECD 401

read across from OCTANOIC ACID ( CAS 124-07-2) LC50 INHALATION , RAT > 0.1621 mg/L air

(published data)

read across from STEARIC ACID ( CAS 57-11-4) LD50 DERMAL , RABBIT > 2000 mg/kg bw

OECD 434

S KIN CORROSION / IRRITATION :

A ZELAIC ACID is not skin irritating at concentrations up to 50% in a guinea pig test according to OECD 406. The liquid analogue F ATTY ACIDS , C 8-10 (CAS 68937-75-7) is skin irritating in a rabbit test according to OECD 404 (degree of purity > 99.5%). Based on above results, A ZELAIC ACID is classified as skin irritant in concentrations above 50%. Rabbit study on the analogue: C10: 96.6 %; C12: 2.6 %; C8: 0.8 % shows corneal opacity and moderate conjunctivitis which do not subside within 72 h. Based on above results, A ZELAIC ACID is classified as eye irritant.

S ERIOUS EYE DAMAGE / IRRITATION :

R ESPIRATORY OR SKIN SENSITIZATION :

RESPIRATORY : No available information.

REGULATION (EC) No 1907/2006 Date of Issue: 02/01/2020

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Date of Revision: - AZCO99 Revision Nr.: - Version Nr.: 1