Azeco Cosmeceuticals

AZECO COSMECEUTICALS BV - MUSSENBERG 1, 6049 GZ Herten, The Netherlands – Phone: +31 475 206070

10.1. T ITLE SECTION Intermediate (PC 19); Manufacture of bulk, large scale chemicals (including petroleum products) (SU 8) Manufacture of fine chemicals (SU 9) E NVIRONMENT Contributing Scenario 1 : Use at industrial site W ORKER Contributing Scenario 2 : Use in closed process, no likelihood of exposure

ERC 6a

PROC 1 Contributing Scenario 3 : Use in closed, continuous process with occasional controlled exposure PROC 2 Contributing Scenario 4 : Use in closed batch process (synthesis or formulation) PROC 3 Contributing Scenario 5 : Use in batch and other processes (synthesis) where opportunity for exposure arises PROC 4 Contributing Scenario 6 : Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at not dedicated facilities PROC 8a Contributing Scenario 7 : Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities PROC 8b Contributing Scenario 8 : Transfer of substance or preparation into small containers (dedicated filling line, including weighing) Industrial settings PROC 9 Contributing Scenario 9 : Use as laboratory agent PROC 15

10.2. C ONDITIONS OF USE AFFECTING EXPOSURE

10.2. C ONTROL OF ENVIRONMENTAL EXPOSURE : U SE AT INDUSTRIAL SITE (ERC 6 a )

In consideration of the chemical safety assessment, performed for this substance according to Article 14 (3) of the REACH regulation, all identified uses of azelaic acid are assessed as safe for the environment.

10.2.2. C ONTROL OF WORKER EXPOSURE : U SE IN CLOSED PROCESS , NO LIKELIHOOD OF EXPOSURE (PROC 1)

P RODUCT ( ARTICLE ) CHARACTERISTICS Covers percentage substance in the product up to 100 % A MOUNT USED ( OR CONTAINED IN ARTICLES ), FREQUENCY AND DURATION OF USE / EXPOSURE Covers daily exposures up to 8 hours T ECHNICAL AND ORGANISATIONAL CONDITIONS AND MEASURES Provide a basic standard of general ventilation (1 to 3 air changes per hour)

Use in closed process, no likelihood of exposure Advanced (industrial) exposure controls assumed O THER CONDITIONS AFFECTING WORKERS EXPOSURE Indoor use Assumes elevated process temperature up to 40.0 °C

10.2.3. C ONTROL OF WORKER EXPOSURE : U SE IN CLOSED , CONTINUOUS PROCESS WITH OCCASIONAL CONTROLLED EXPOSURE (PROC 2)

P RODUCT ( ARTICLE ) CHARACTERISTICS

REGULATION (EC) No 1907/2006 Date of Issue: 02/01/2020

Page 49 of 58

Date of Revision: - AZCO99 Revision Nr.: - Version Nr.: 1