Azeco Cosmeceuticals

AZECO COSMECEUTICALS BV - MUSSENBERG 1, 6049 GZ Herten, The Netherlands – Phone: +31 475 206070

E XP . S CENARIO

M ARKET S ECTOR

T ITLES OF EXPOSURE SCENARIOS AND THE RELATED CONTRIBUTING SCENARIOS

- Calendering operations (PROC 6) - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at not dedicated facilities (PROC 8a) - Transfer of substance or preparation (charging/discharging) from/to vessel/large containers at dedicated facilities (PROC 8b) - Transfer of substance or preparation into small containers (dedicated filling line, including weighing) Industrial settings (PROC 9) - Roller application or brushing (PROC 10) - Treatment of articles by dipping and pouring (PROC 13) U SE AS CHEMICAL INTERMEDIATE AT INDUSTRIAL SITE - Use sat industrial site (ERC 6a) - Use in closed process, no likelihood of exposure (PROC 1) - Use in closed, continuous process with occasional controlled exposure (PROC 2) - Use in closed batch process (synthesis or formulation) (PROC 3) - Use in batch and other processes (synthesis) where opportunity for exposure arises (PROC 4) - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at not dedicated facilities (PROC 8a) - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities (PROC 8b) - Transfer of substance or preparation into small containers (dedicated filling line, including weighing) Industrial settings (PROC 9) - Use as laboratory agent (PROC 15) U SE AS A MONOMER AT INDUSTRIAL SITE - Use at industrial site (ERC 6c) - Use in closed process, no likelihood of exposure (PROC 1) - Use in closed, continuous process with occasional controlled exposure (PROC 2) - Use in closed batch process (synthesis or formulation) (PROC 3) - Use in batch and other processes (synthesis) where opportunity for exposure arises (PROC 4) - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at not dedicated facilities (PROC 8a) - Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities (PROC 8b) - Transfer of substance or preparation into small containers (dedicated filling line, including weighing) Industrial settings (PROC 9) - Use as laboratory agent (PROC 15)

ES10 – IW5

PC 19

ES11 - IW6

PC 32

U SE AT INDUSTRIAL SITE - U SE IN LABORATORIES - Use in laboratories (ERC 4) - Roller application or brushing (PROC 10) - Use as laboratory agent (PROC 15) U SE BY PROFESSIONAL WORKER - U SE IN LABORATORIES - Use in laboratories (ERC 8a) - Roller application or brushing (PROC 10) - Use as laboratory agent (PROC 15)

ES12– IW7

PC 21

ES13 – PW4

PC 21

* About the use in personal care products and in drugs of azelaic acid, no exposure scenarios are calculated for these applications because these uses are exempt from REACH human assessment, already regulated respectively by the 1223/2009 EC and the 2001/83 EC. Acronyms ACGIH = American Conference of Governmental Industrial Hygienists DNEL = Derived No Effect Level EC50 = Effective Concentration 50: concentration that causes a certain effect in 50% of a population EINECS = European Inventory of Existing Commercial chemical Substances ErC50 = EC50 (growth rate): EC50 biomass growth of aquatic plants LC50 = Lethal Concentration 50: concentration that causes the death of 50% of population LD50 = Lethal Dose 50: dose that causes the death of 50% of population NOAEL = No Observed Adverse Effect Level: dose or concentration without adverse effect OECD = Organization for Economic Co-operation and Development OSHA PEL = Occupational Safety and Health Administration-Permissible Exposure Limit PNEC = Predicted No Effect Concentration TLV = Threshold Limit Value

REGULATION (EC) No 1907/2006 Date of Issue: 02/01/2020

Page 13 of 58

Date of Revision: - AZCO99 Revision Nr.: - Version Nr.: 1