Azeco Cosmeceuticals

AZECO COSMECEUTICALS BV - MUSSENBERG 1, 6049 GZ Herten, The Netherlands – Phone: +31 475 206070

The liquid analogue F ATTY ACIDS , C 8-10 (CAS 68937-75-7) is skin irritating in a rabbit test according to OECD 404 (degree of purity > 99.5%). Based on above results, A ZELAIC ACID is classified as skin irritant in concentrations above 50%. Rabbit study on the analogue: C10: 96.6 %; C12: 2.6 %; C8: 0.8 % shows corneal opacity and moderate conjunctivitis which do not subside within 72 h. Based on above results, A ZELAIC ACID is classified as eye irritant. SKIN : A ZELAIC ACID is not sensitizing in the guinea pig test according to OECD 406 at concentrations up to 50%. Also studies on analogues do not show sensitizing phenomena. No data available on germ cells. Experimental tests carried out on analogues show negative results in bacteria reverse mutation on S. typhimurium and genetic mutation and chromosome aberration tests on mammalian cells. No in vivo available experiments. In vitro experimental tests carried out on analogues show negative results in bacteria reverse mutation on S. typhimurium and genetic mutation and chromosome aberration tests on mammalian cells. The analogue DOCOSANOIC ACID (CAS 112-85-6) does not show any adverse effects on rats maternal and foetal development at the maximum dose (1000 mg/kg bw) according to OECD 422. RESPIRATORY : No available information.

S ERIOUS EYE DAMAGE / IRRITATION :

R ESPIRATORY OR SKIN SENSITIZATION :

G ERM CELL MUTAGENICITY :

C ARCINOGENICITY :

R EPRODUCTIVE TOXICITY :

STOT- SINGLE EXPOSURE :

No available information

STOT- REPEATED EXPOSURE :

No available information

A SPIRATION HAZARD :

No available information.

S ECTION 12: E COLOGICAL INFORMATION

EC50 (72h, Algae ) > 100 mg/L ErC50 (72h, Algae ) > 67 mg/L

12.1. T OXICITY :

OECD 201 OECD 201

12.2. P ERSISTENCE AND DEGRADABILITY :

The substance is readily biodegradable.

12.3. B IOACCUMULATIVE POTENTIAL :

Based on the Log Kow ( PARTITION COEFFICIENT N - OCTANOL / WATER ) of 1,57 the BCF (B IO C ONCENTRATION F ACTOR ) of 3,162 can be estimated (BCFWINNT v.2.15). Therefore, Bioaccumulation potential is low.

REGULATION (EC) No 1907/2006 Date of Issue: 02/01/2020

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Date of Revision: - AZCO99 Revision Nr.: - Version Nr.: 1