Azeco Cosmeceuticals

AZECO COSMECEUTICALS BV - MUSSENBERG 1, 6049 GZ Herten, The Netherlands – Phone: +31 475 782540

Contributing Scenario 1 : Use as rubber additive

ERC 4, ERC 5, ERC 6b, ERC 6d

W ORKER Contributing Scenario 2 : Use in closed batch process (synthesis or formulation) Contributing Scenario 3 : Use in batch and other processes(synthesis) where opportunity for exposure arises Contributing Scenario 4 : Mixing or blending in batch processes for formulation of preparations and articles Contributing Scenario 6 : Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at not dedicated facilities Contributing Scenario 7 : Transfer of substance or preparation (charging/discharging) from/to vessel/large containers at dedicated facilities Contributing Scenario 8 : Transfer of substance or preparation into small containers (dedicated filling line, including weighing) Industrial settings Contributing Scenario 5 : Calander operations

PROC 3

PROC 4

PROC 5

PROC 6

PROC 8a

PROC 8b

PROC 9

Contributing Scenario 9 : Roller application or brushing

PROC 10

Contributing Scenario 10 : Treatment of articles by dipping and pouring

PROC 13

Contributing Scenario 11 : Production of preparations or articles by tabletting, compression, extrusion, pelletisation

PROC 14

9.2. C ONDITIONS OF USE AFFECTING EXPOSURE

9.2.1. C ONTROL OF ENVIRONMENTAL EXPOSURE : U SE AS A RUBBER ADDITIVE (ERC 4, ERC 5, ERC 6 b , ERC 6 d )

In consideration of the chemical safety assessment, performed for this substance according to Article 14 (3) of the REACH regulation, all identified uses of azelaic acid are assessed as safe for the environment

9.2.2. C ONTROL OF WORKER EXPOSURE : U SE IN CLOSED BATCH PROCESS ( SYNTHESIS OR FORMULATION ) (PROC 3)

P RODUCT ( ARTICLE ) CHARACTERISTICS Covers percentage substance in the product up to 100 % A MOUNT USED ( OR CONTAINED IN ARTICLES ), FREQUENCY AND DURATION OF USE / EXPOSURE Covers daily exposures up to 8 hours T ECHNICAL AND ORGANISATIONAL CONDITIONS AND MEASURES Provide a basic standard of general ventilation (1 to 3 air changes per hour)

Use in closed batch process (synthesis or formulation) Advanced (industrial) exposure controls assumed O THER CONDITIONS AFFECTING WORKERS EXPOSURE Indoor use Assumes elevated process temperature up to 40.0 °C

9.2.3. C ONTROL OF WORKER EXPOSURE : U SE IN BATCH AND OTHER PROCESSES ( SYNTHESIS ) WHERE OPPORTUNITY FOR EXPOSURE ARISES (PROC 4)

P RODUCT ( ARTICLE ) CHARACTERISTICS Covers percentage substance in the product up to 100 %

REGULATION (EC) No 1907/2006 Date of Issue: 02/01/2020

Page 43 of 56

Date of Revision: - AZCO99 Revision Nr.: - Version Nr.: 1