Azeco Cosmeceuticals

Question: I have a question concerning the solubility of the acid, I’ve tried various tests in the laborato- ry and I have not been able to solubilize it. I have tried a few solubility tests in the laboratory and I’ve made a solution of 0,79 % Azelaic acid and it has NOT completely solubilized. Do you mean 10-15 % acid in Propanediol? Can you please give me the contact details to a technician who can help me with this. Answer Such a base formulation can be generated by dissolution of azelaic acid in propanediol (Zemea, ex.Dupont), chemically identified as 1,3-propanediol. The solution of azelaic acid in propanediol does not require preservation and may be thickened using 3-4% hydroxy- propylcellulose (HPC; Ashland). To the obtained gel other active ingredients can be added, provided the additive is miscible with the azelaic acid/propanediol gel. That is the case for hydrophilic extracts, but also oil-in-water emulsions. The solubility of azelaic acid in propanediol is relatively high. We frequently use solutions of 10-15%. We do not know what the maximum solubility of azelaic acid in propanediol would be. That would need to be researched. Note that gelation of propanediol with HPC is a tedious process. Does this answer your question?

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