Azeco Cosmeceuticals

Manufacturing instructions: 1.

The water phase (Phase A) is prepared by combining the ingredients. The water phase shall be alkaline as to (partially) neu tralise azelaic acid present in the oil phase. Ignoring to do so will inhibit emulsion formation. The water phase is heated to 70-75°C.

2. The oil phase (Phase B) is made by combining the ingredients and heating to 70-75°C. The oil phase shall be completely clear, and has a slight yellowish colour.

3. The oil phase is added to the water phase at 70-75°C while stirring with a planetary mixer. The mixture, that is still unstable, is stirred during 5 minutes (on a laboratory scale). Subsequently the mixture is homogenised using a high velocity rotor-stator mixer at maximum capacity. The pre-emulsion is cooled to 40-45°C and re-homogenised adding the preservative (Phase C). The obtained emulsion is white and is still low viscous. Upon further cooling the viscosity will continue to increase. At 25°C the fragrance is added (Phase D); stirring is continued during 15 minutes. 4. The pH is adjusted to the specifications with an 18% aqueous sodium hydroxide solution. The lotion is kept in quarantine for 5 days and committed for microbiological analysis. After 5 days the analytical data of the lotion may be adjusted to the specifica tions, if required. After the quarantine period the lotion may be committed for confectioning or transferred to bulk storage, provided it satisfies the specifications. INCI list: Ingredients: Aqua, Caprylic/Capric Triglyceride, Azelaic Acid, Glyceryl Stearate, Betaine, Glycerin, Isopropyl Myristate, PEG-20 Glyce ryl Stearate, Cetearyl Alcohol, Diethylhexyl Adipate, Ceteareth-20, Ceteareth-12, Cetyl Palmitate, Parfum, Phenoxyethanol, Sorbitan Caprylate. SC003 Oil-free serum for skin with disorders (skin prone to acne) - Triple action: anti-imperfections, anti-residual marks, anti-aging. INCI Name Trade name / Other name % by weight Function A Aqua Water 10.00 Solvent Propanediol Propylen Glycol 10.00 Humectant Heptyl glucoside Sepiclear G7 [1] 10.00 Emulsifier Azelaic acid Azepur99® 10.00 Active Ingredient B Xylityl sesquicaprylate Hebeatol plus [2] 0.5 Antimicrobial and Moisturizing Agent Tocopheryl Acetate Vitamin E acetate 0.05 Antioxidant, Antiaging agent C Phenoxyethanol - 0.30 Preservative Sodium Polyacryloyldimethyl Taurate Aristoflex silk [3] 1.00 Rheology Modifier Aqua Water 57,9 Solvent Dimethyl Isosorbide (and) Hydroxypinacolone Retinoate Granactive Retinoid [4] 0.10 Antiaging agent D Parfum - 0.15 Fragrance Shelf life: 3 years after production, 12 months after opening. Store at ambient temperature, out of direct sun light. Preferred pack aging: tube, 30 ml.

Mussenberg 1 • 6049 GZ Roermond • The Netherlands

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