Azeco Cosmeceuticals

Scalpcare Azepur99®, a 100% biobased, high-purity azelaic acid—represents the next generation of scalp care innovation. Sourced from high oleic sunflower oil of European origin and COSMOS certified, Azepur99® responds to the increasing demand for safe, natural, and effective active ingredients in personal care formulations. Scalp care, once overlooked in haircare protocols, has become a key factor in maintaining healthy, resilient hair. Functional Properties of Azepur99® Azepur99® exhibits multiple biofunctional benefits: 5- α -reductase inhibition: By blocking this enzyme, Azepur99® decreases the formation of DHT (dihydrotestosterone), a central factor in androgenetic alopecia. Anti-inflammatory and antioxidant action: Soothes inflamed follicles and protects against oxidative stress. Antimicrobial effects: Helps regulate scalp microbiota, reducing fungal and bacterial contributors to irritation and hair loss. These mechanisms support an optimal scalp environment, essential for hair follicle vitality and hair growth stimulation. Clinical Efficacy Study Evaluation of a 10% Azepur99® scalp serum over 90 days. To validate the efficacy of Azepur99® in a scalp care formulation, a 90-day clinical study was performed using a scalp serum containing 10% Azepur99®.

Study objectives The primary aims of the study were to evaluate: 1.Hair density improvement 2.Scalp barrier function and resilience 3.Reduction in scalp sensitivity and discomfort

Study design Duration: 90 consecutive days of daily application Participants: A mixed-gender panel of healthy adult volunteers experiencing scalp sensitivity and/or mild hair thinning Product tested: Serum containing 10% Azepur99® as the active ingredient Application protocol: Participants applied the product once daily to the scalp, following standardized instructions Methods of Evaluation A combination of instrumental techniques and subjective questionnaires was used to measure effectiveness: Hair density: Quantified using high-resolution scalp photography and trichoscopy to count hair strands per cm² Scalp barrier function: Measured via transepidermal water loss (TEWL) and corneometry Sensitivity: Evaluated through participant feedback, visual scaling of erythema and itching, and self-reported questionnaires Tolerability and user satisfaction: Tracked through regular interviews and observation by clinical dermatologists

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Phone : +31 475 20 60 70 • service@azeco-cosmeceuticals.com • www.azeco-cosmeceuticals.com