Azeco Cosmeceuticals

44. Question: What percentage of Azelaic is recommended for professional use versus home care use?

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45. Question: What is the highest % of Azelaic acid that can be used in cosmetics in EU and the USA.

Regulatory 46. Question: Is Azelaic acid standardized in the US Pharmacopeia or India Pharmacopeia?

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47. Question: The main CAS of the product is “123-99-9”, however, in section 11 there are 4 more CAS present (112-85-6, 57-11-4, 124-07-2, 68937-75-7). Kindly confirm are these 4 components are part of the product?

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48. Question: Is Azepur99® tested on animals?

49. Question: Is Azepur99® cosmetic grade TSCA (USA) and ENCS (Japan) registered?

Functionality 50. Question: If a consumer stops using the product with Azelaic acid for skin prone to acne, how long will the effects last after stopping? 51. Question: Can you share the MIC-value of Azelaic acid and what dosage is recommended? T his to indicate the antimicrobial effect.

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52. Question: Could you advise on the packaging material for formulations with Azelaic acid?

We have to check the stability in several materials sucha s PP or PE.

Applications 53. Question: Can Azelaic acid be used as a preservative or co-preservative in cosmetic products?

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54. Question: How long is it recommended to leave an exfoliant on the skin for it to penetrate? 23 55. Question: Azelaic acid can be used during pregnancy. Can it also be used during breast- feeding/lactancy period? 23 56. Question: If Azelaic acid can be used for hair (re)growth products, what consequence does this have for growing 23 facial hair (women) when used in skin products for the face? Azelaic acid and other ingredients 57. Question: Are there skincare ingredients that should not be combined with Azelaic acid? For example Retinol? 24 58. Question: We currently using Vitamin A and Vitamin C in a skin whitening application. Both can cause skin irritation. Is there a comparative table available where the different adverse effects are showed for Vitamin A and Vitamin C compared to Azelaic acid. 24

Mussenberg 1 • 6049 GZ Herten • The Netherlands

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