Azeco Cosmeceuticals

21. Question: I premix my Azelaic acid (7%) in propanediol (15%) I get a white mixture, do I need to neutralize the acid with sodium hydroxide at pH 6-7? 13 22. Question: According to formula SC003, Is it possible to have a oil free serum at pH 4.5-5 with high bioavailability? 13 23. Question: Does Azelaic acid have a higher bioavailability at pH 6-7 or 5 in the finished 13 product? 13 24. Question: Why in your formulation example (SC003) of the oil free serum for skin with disorders you do not neutralize the Azelaic acid with sodium hydroxide at pH 6-7? 14 25. Question: For an O/W emulsion, can Azelaic acid be added in the aqueous phase (water + propanediol)? Or should it be neutralized with sodium hydroxide at pH 6-7? 14 26. Question: In your formulation example (SC001) anti acne - asian formula is there no recrystallization problem since your pH is at 4.9-5.6? 14 27. Question: Do you advise including Azelaic acid in haircolouring products in view of pH 14 grade and possible scalp irritation? 14 28. Question: For developing a 15% peel, but don’t use too much ethanol. How to get a good solution? 14 29. Question: Is the bioavailability of Azepur99® better in emulsion? 14 30. Question: What is the most effective level of use for treating androgenic alopecia? We have so far put the Azelaic acid into propylene glycol and glycerine with some ethanol, but this can be too heavy. What is the best mixture to use as a carrier? 15 31. Question: Which pH is applicable for peelings? 15 32. Question: At what stage Azelaic acid should be added in a formulation to obtain the texture of a product in cream or lotion? 15 33. Question: What would be the effect of a lower dosage (3%-5%) of Azelaic acid combined with other ingredients 16 in a skincare formulation? 34. Question: Are there any more detailed solubility data in various polar oils to share? 16 35. Question: Question regarding an emulsion with 15% Azelaic acid: after several tests we still have problems. 16 36. Question: What is the maximum pH in order to guarantee the effectiveness of Azelaic acid? 37. Question: Can Azelaic acid be solubilised using only Ethanol? What would be the recommended proportion Azelaic acid and Ethanol in case of adding another active ingredient? 16 38. Question: What is a good subsitute for Polysorbate-80 for COSMOS/ECOCERT products? 16 Dosage of finished forms 39. Question: What is the method of Azelaic acid assay in cream as finished product? 17 40. Question: Is the action of Azelaic acid dosage dependent? And is transdermal transport also a factor? 19 41. Question: What is the best recommended dosage of Azelaic acid for an anti acne 19 formulation. And what would be the best formulating pH range? 19 42. Question: What is the best recommended dosage of Azelaic acid for skin lightening and anti-dark spots formulation. What would be the best formulating pH range? 19 43. Question: Is the pH for a cream lower than for a serum? 19

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