Azeco Cosmeceuticals

Formulations

24. Question: Why in your formulation example (SC003) of the oil free serum for skin with di sorders you do not neutralize the Azelaic acid with sodium hydroxide at pH 6-7? In this formula does the Azelaic acid have a high bioavailability? Why your pH of the finished product is bet ween 3.4 - 3.6 is there no recrystallization problem? Answer: In this case the dispersion of Azelaic acid is strongly improved by the addition of a high amount of emulsifier (microemulsion) Sepiclear G7. The bioavalaibility is high because Azelaic acid is present in the neutral form (acidic). 25. Question: For an O/W emulsion, can Azelaic acid be added in the aqueous phase (water + propanediol)? Or should it be neutralized with sodium hydroxide at pH 6-7? Answer: If water is present, a small amount of sodium hidroxide can increase the solubility. For more information see our Skincare brochure. https://azelaicacid.cld.bz/Azeco-Cosmeceuticals-Library-download/Azeco-Cosmeceuticals11 26. Question: In your formulation example (SC001) anti acne - asian formula is there no recrys tallization problem since your pH is at 4.9-5.6? Answer: The product was stable for all the storage stability test (6 months at 40°C). 27. Question: Do you advise including Azelaic acid in haircolouring products in view of pH grade and possible scalp irritation? Answer: The addition of Azelaic acid in hair color cosmetics is not recommendable because their pH is very high, and this can eliminate any positive action of Azelaic acid. At that pH, all Azelaic acid is transformed in sodium and or MEA azelate, that is not absorbed by the skin). 28. Question: For developing a 15% peel, but don’t use too much ethanol. How to get a good solution? Answer: Glycols are better solubilizers than ethanol. You can use for example propylen glycol or butylen glycol in substitution of part of ethanol. 29. Question: Is the bioavailability of Azepur99® better in emulsion?

Answer: No it does not relate to this, in general it is the presence of glycols that is able to improve bioavailability.

Mussenberg 1 • 6049 GZ Herten • The Netherlands

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